In recent years, skin boosters such as Profhilo vs Rejuran have become some of the most sought-after treatments in aesthetic medicine. Unlike traditional fillers, which focus on adding volume or reshaping facial features, skin boosters work at a deeper level to improve skin quality, hydration, and elasticity. They are especially popular for anti-aging because they rejuvenate the skin from within, giving a natural and youthful glow without altering facial structure.
Two of the most talked-about treatments in this category are Profhilo and Rejuran. Both are designed to refresh and repair the skin, but they work in different ways. Many people search for “Profhilo vs Rejuran” or wonder whether “Profhilo or Rejuran” is better for their skin concerns. Understanding the differences between these two treatments can help you make the right choice for your skin goals.
What is Rejuran?
Rejuran is a popular skin booster made from polynucleotides (PN), sometimes referred to as PDRN (polydeoxyribonucleotide). These are DNA fragments extracted from salmon that are highly compatible with human skin, making Rejuran safe and effective for natural skin rejuvenation.
The treatment works by stimulating collagen production, repairing damaged skin cells, and improving overall texture and elasticity. Unlike traditional dermal fillers that simply add volume, Rejuran focuses on long-term skin healing and regeneration.
Key Benefits of Rejuran
- Promotes skin repair and healing at the cellular level by stimulating fibroblasts and collagen production.
- Provides strong anti-inflammatory effects, reducing redness, irritation, and sensitivity.
- Improves elasticity, firmness, and smoothness, making skin look healthier and more youthful.
- Helps minimize fine lines and early wrinkles by strengthening the skin barrier.
- Restores a natural, radiant glow while targeting signs of premature aging.
- Enhances skin texture by refining enlarged pores and rough patches.
Who is Rejuran Best For?
- Acne scars, enlarged pores, or uneven texture
- Fine lines, wrinkles, or early signs of aging
- Sensitive, thin, or easily damaged skin needing repair
- Dull, rough, or tired-looking skin that lacks vitality
- Patients seeking a natural treatment option with minimal downtime
What is Profhilo?
Profhilo is an advanced injectable treatment made with a high concentration of pure hyaluronic acid (HA). Unlike traditional dermal fillers, it doesn’t add artificial volume or change facial contours. Instead, it acts as a powerful skin hydrator and bio-remodeler, improving skin quality, firmness, and glow from within.
Profhilo gradually spreads under the skin after injection, releasing hyaluronic acid that deeply hydrates tissues, stimulates collagen and elastin, and remodels sagging areas. The result is skin that looks smoother, plumper, and naturally refreshed.
Key Benefits of Profhilo
- Intense, long-lasting hydration that restores moisture balance.
- Boosts collagen and elastin production, improving skin strength.
- Reduces crepey texture on the face, neck, and décolletage.
- Firms and tightens sagging or lax skin without adding volume.
- Creates a natural, radiant glow that looks healthy and youthful.
- Minimal downtime compared to many other injectable treatments.
Who is Profhilo Best For?
Profhilo is especially suited for individuals who:
- Struggle with dry, dehydrated, or dull skin despite skincare products.
- Show early to moderate signs of aging, such as fine lines and wrinkles.
- Experience skin laxity or sagging around the cheeks, jawline, or neck.
- Want to improve overall skin firmness, smoothness, and elasticity.
- Prefer a natural-looking anti-aging solution without added bulk or filler effect.
Key Differences of Profhilo vs Rejuran
While both treatments aim to rejuvenate the skin, Profhilo and Rejuran work in very different ways. Profhilo is designed to deeply hydrate and bio-remodel aging skin using hyaluronic acid, while Rejuran skin booster focuses on regeneration and repair through polynucleotides.
The table below highlights the main differences to help you decide which treatment suits your needs best.
| Features |
Profhilo |
Rejuran |
| Composition |
High concentration of hyaluronic acid (HA) |
Polynucleotides (PN) / PDRN, DNA fragments that repair skin |
| Primary Purpose |
Deep hydration, bio-remodeling, tightening |
Skin healing, regeneration, and anti-inflammatory repair |
| Best For |
Dehydrated, sagging, dull or aging skin |
Sensitive, scarred, or damaged skin with fine lines |
| Treatment Areas |
Face, neck, décolletage, hands |
Face, under-eye, neck, acne-scarred or damaged areas |
| Sessions Required |
Usually 2 sessions, 4 weeks apart |
Typically 3–4 sessions, spaced 3–4 weeks apart |
| Longevity of Results |
Around 6–9 months, depending on skin |
Around 6–12 months, depending on condition |
| Downtime |
Minimal: mild redness or bumps for 24–48 hrs |
Slight swelling, redness, or bumps for 2–3 days |
| Aftercare |
Avoid makeup, saunas, and intense exercise for 24 hrs |
Avoid sun, heat exposure, and strenuous activity for 48 hrs |
Can Profhilo and Rejuran Be Combined?
Yes, many clinics now recommend a combination approach using both Profhilo and Rejuran to maximize results. Since they work in different ways, they can complement each other rather than compete.
- Profhilo delivers intense hydration and stimulates collagen and elastin for firmer, more youthful-looking skin.
- Rejuran focuses on skin regeneration, healing, and repairing cellular damage.
When Does Combination Therapy Make Sense?
Using both treatments may be especially beneficial for individuals who:
- Want hydration and glow along with healing and repair.
- Have multiple skin concerns such as dryness, sagging, and acne scars.
- Are looking for a comprehensive anti-aging plan rather than targeting a single issue.
- Prefer a natural outcome with gradual but visible improvements.
Potential Enhanced Results
When combined, Profhilo and Rejuran can:
- Improve skin texture, tone, and elasticity at the same time.
- Reduce fine lines, wrinkles, and scars more effectively.
- Deliver a healthier, firmer, and more radiant complexion than either treatment alone.
- Extend the longevity of results when administered in alternating treatment sessions.
Which Should You Choose Profhilo or Rejuran?
Choosing between Profhilo or Rejuran depends on your age, skin concerns, and treatment goals. Both are excellent options, but they target different needs.
Factors to Consider
-
Age: Younger patients may benefit from Rejuran’s regenerative properties, while those experiencing early to moderate skin laxity often see better results with Profhilo.
-
Skin Concerns: Consider whether you need hydration, repair, or both.
-
Goals: Are you aiming for smoother texture and scar reduction, or overall firmness and glow?
Rejuran: If your main concerns are acne scars, rough skin texture, or dull and tired-looking skin, then Rejuran is often the better choice. It works at a cellular level to repair damage, stimulate healing, and reduce fine lines. Rejuran is also well-suited for individuals with sensitive or easily damaged skin who want long-term regeneration and stronger skin health.
Profhilo: If your goal is deep hydration, improved elasticity, and a natural anti-aging glow, then Profhilo may be more suitable. By delivering high concentrations of hyaluronic acid, Profhilo helps plump the skin, restore firmness, and enhance overall radiance. It is ideal for those looking to combat sagging, dryness, or early signs of aging with natural, glowing results.
Treatment Experience
Both Profhilo and Rejuran are administered through a series of tiny injections into targeted areas of the skin. The treatment usually takes 20–30 minutes and is performed in a clinic setting by a qualified professional.
Pain/Discomfort Levels
-
Profhilo: Generally mild discomfort as it uses fewer injection points (often 5 on each side of the face).
-
Rejuran: May feel slightly more uncomfortable because it requires multiple micro-injections across the treatment area. A topical numbing cream is typically applied to reduce pain.
Recovery Time
-
Profhilo: Small bumps or redness may appear at injection points but usually settle within 24–48 hours.
-
Rejuran: Slight swelling or pinpoint marks may last 2–3 days before fading.
Both profhilo and rejuran treatments involve minimal downtime, and most patients can return to daily activities the same day.
Cost of Profhilo vs Rejuran Treatments
The cost of Profhilo and Rejuran treatments can vary depending on the clinic, city, and the number of sessions required. On average:
Profhilo: Typically costs between $700–$1,200 per session, with most patients needing 2 sessions about 4 weeks apart. Results last around 6–9 months.
Rejuran: Usually priced between $500–$900 per session, but requires 3–4 sessions for best results. Outcomes can last 6–12 months depending on skin condition.
Conclusion
In the debate of Profhilo vs Rejuran, the best choice depends on your skin’s needs. Profhilo is ideal for hydration, firmness, and glow, while Rejuran excels in repair, healing, and regeneration. For many patients, combining both delivers the most comprehensive results. Always consult a qualified practitioner to determine the right treatment for your skin goals.
FAQs
Is Rejuran or Profhilo better for anti-aging?
Both can address signs of aging, but in different ways. Profhilo is excellent for improving hydration, firmness, and glow, while Rejuran focuses on cellular repair and reducing fine lines. Many patients combine them for optimal results.
Can you do Profhilo and Rejuran in the same session?
Yes, they can be used together since they serve different purposes. Some clinics recommend alternating or combining them for enhanced results, depending on your skin concerns.
How long do results last?
Profhilo: Around 6–9 months, depending on age and lifestyle. Rejuran: Around 6–12 months, depending on skin condition and number of sessions.
Which has less downtime?
Profhilo generally has less downtime since it uses fewer injection points. Rejuran may leave slightly more swelling or redness, lasting up to 2–3 days.
Profhilo vs Rejuran: Key Differences, Benefits & Which to Choose
In recent years, skin boosters such as Profhilo vs Rejuran have become some of the most sought-after treatments in aesthetic medicine. Unlike traditional fillers, which focus on adding volume or reshaping facial features, skin boosters work at a deeper level to improve skin quality, hydration, and elasticity. They are especially popular for anti-aging because they rejuvenate the skin from within, giving a natural and youthful glow without altering facial structure.
Two of the most talked-about treatments in this category are Profhilo and Rejuran. Both are designed to refresh and repair the skin, but they work in different ways. Many people search for “Profhilo vs Rejuran” or wonder whether “Profhilo or Rejuran” is better for their skin concerns. Understanding the differences between these two treatments can help you make the right choice for your skin goals.
What is Rejuran?
Rejuran is a popular skin booster made from polynucleotides (PN), sometimes referred to as PDRN (polydeoxyribonucleotide). These are DNA fragments extracted from salmon that are highly compatible with human skin, making Rejuran safe and effective for natural skin rejuvenation.
The treatment works by stimulating collagen production, repairing damaged skin cells, and improving overall texture and elasticity. Unlike traditional dermal fillers that simply add volume, Rejuran focuses on long-term skin healing and regeneration.
Key Benefits of Rejuran
Who is Rejuran Best For?
What is Profhilo?
Profhilo is an advanced injectable treatment made with a high concentration of pure hyaluronic acid (HA). Unlike traditional dermal fillers, it doesn’t add artificial volume or change facial contours. Instead, it acts as a powerful skin hydrator and bio-remodeler, improving skin quality, firmness, and glow from within.
Profhilo gradually spreads under the skin after injection, releasing hyaluronic acid that deeply hydrates tissues, stimulates collagen and elastin, and remodels sagging areas. The result is skin that looks smoother, plumper, and naturally refreshed.
Key Benefits of Profhilo
Who is Profhilo Best For?
Profhilo is especially suited for individuals who:
Key Differences of Profhilo vs Rejuran
While both treatments aim to rejuvenate the skin, Profhilo and Rejuran work in very different ways. Profhilo is designed to deeply hydrate and bio-remodel aging skin using hyaluronic acid, while Rejuran skin booster focuses on regeneration and repair through polynucleotides.
The table below highlights the main differences to help you decide which treatment suits your needs best.
Can Profhilo and Rejuran Be Combined?
Yes, many clinics now recommend a combination approach using both Profhilo and Rejuran to maximize results. Since they work in different ways, they can complement each other rather than compete.
When Does Combination Therapy Make Sense?
Using both treatments may be especially beneficial for individuals who:
Potential Enhanced Results
When combined, Profhilo and Rejuran can:
Which Should You Choose Profhilo or Rejuran?
Choosing between Profhilo or Rejuran depends on your age, skin concerns, and treatment goals. Both are excellent options, but they target different needs.
Factors to Consider
Rejuran: If your main concerns are acne scars, rough skin texture, or dull and tired-looking skin, then Rejuran is often the better choice. It works at a cellular level to repair damage, stimulate healing, and reduce fine lines. Rejuran is also well-suited for individuals with sensitive or easily damaged skin who want long-term regeneration and stronger skin health.
Profhilo: If your goal is deep hydration, improved elasticity, and a natural anti-aging glow, then Profhilo may be more suitable. By delivering high concentrations of hyaluronic acid, Profhilo helps plump the skin, restore firmness, and enhance overall radiance. It is ideal for those looking to combat sagging, dryness, or early signs of aging with natural, glowing results.
Treatment Experience
Both Profhilo and Rejuran are administered through a series of tiny injections into targeted areas of the skin. The treatment usually takes 20–30 minutes and is performed in a clinic setting by a qualified professional.
Pain/Discomfort Levels
Recovery Time
Both profhilo and rejuran treatments involve minimal downtime, and most patients can return to daily activities the same day.
Cost of Profhilo vs Rejuran Treatments
The cost of Profhilo and Rejuran treatments can vary depending on the clinic, city, and the number of sessions required. On average:
Profhilo: Typically costs between $700–$1,200 per session, with most patients needing 2 sessions about 4 weeks apart. Results last around 6–9 months.
Rejuran: Usually priced between $500–$900 per session, but requires 3–4 sessions for best results. Outcomes can last 6–12 months depending on skin condition.
Conclusion
In the debate of Profhilo vs Rejuran, the best choice depends on your skin’s needs. Profhilo is ideal for hydration, firmness, and glow, while Rejuran excels in repair, healing, and regeneration. For many patients, combining both delivers the most comprehensive results. Always consult a qualified practitioner to determine the right treatment for your skin goals.
FAQs
Is Rejuran or Profhilo better for anti-aging?
Both can address signs of aging, but in different ways. Profhilo is excellent for improving hydration, firmness, and glow, while Rejuran focuses on cellular repair and reducing fine lines. Many patients combine them for optimal results.
Can you do Profhilo and Rejuran in the same session?
Yes, they can be used together since they serve different purposes. Some clinics recommend alternating or combining them for enhanced results, depending on your skin concerns.
How long do results last?
Profhilo: Around 6–9 months, depending on age and lifestyle. Rejuran: Around 6–12 months, depending on skin condition and number of sessions.
Which has less downtime?
Profhilo generally has less downtime since it uses fewer injection points. Rejuran may leave slightly more swelling or redness, lasting up to 2–3 days.