Profhilo vs Rejuran: Key Differences, Potential Benefits & Considerations

Advanced Skin Hydration & Revitalisation Treatments

In recent years, non-surgical cosmetic treatments that aim to support skin hydration, texture, and tone have become increasingly popular. These treatments differ from traditional volumising procedures — instead of altering facial structure, they are designed to enhance the appearance of natural skin quality.

Sometimes referred to as injectable hydration treatments or skin boosters, they may be suitable for individuals looking to refresh their skin’s appearance without significantly changing facial contours. Common treatment areas include the face, neck, and décolletage.

At VBeauty, we offer a range of medical-grade cosmetic procedures tailored to your individual skin concerns. During your consultation, our experienced doctors and registered nurses will assess your skin health and goals to recommend a suitable treatment plan.

What These Treatments May Support:

• A smoother or more refined skin texture

• A refreshed or more luminous complexion

• Visible improvement in hydration

• Subtle rejuvenation with minimal downtime

• Skin that appears firmer over time

💧 What Is Rejuran?

Rejuran is a cosmetic injectable treatment that contains polynucleotides (PN) — naturally occurring DNA fragments originally derived from salmon. These molecules are similar in structure to human DNA and are used in aesthetic practice to support skin quality and hydration.

Unlike traditional dermal fillers that add volume, Rejuran is administered into the superficial skin layers with the aim of enhancing the skin's appearance — particularly in terms of texture, tone, and hydration. It is often considered as part of a broader treatment plan to address early signs of skin ageing or dullness.

Commonly Reported Client Outcomes:

While individual responses vary, clients who undergo Rejuran treatments often report:

• Skin that appears more hydrated or refreshed

• Gradual improvement in smoothness or tone

• A softer, more radiant-looking complexion

• Subtle visible changes in the appearance of fine lines

• A general improvement in how the skin feels and looks

Treatment is carried out in a clinical setting by trained practitioners, and usually performed over multiple sessions for optimal results.

👩⚕️ Who Might Consider Rejuran?

Clients often choose Rejuran to support skin concerns such as:

• Uneven texture or rough patches

• Dehydration or dull skin appearance

• Fine lines or early signs of ageing

• Mild scarring (such as from past acne)

• Sensitive or fragile-feeling skin

💧 What Is Profhilo?

Profhilo is a cosmetic injectable treatment that contains a high concentration of hyaluronic acid (HA) — a substance naturally found in the skin that helps maintain hydration.

Unlike traditional dermal fillers, Profhilo is not designed to add volume or reshape facial features. Instead, it is typically used to support overall skin hydration and quality. It is often considered by clients seeking a subtle, refreshed appearance without altering their natural contours.

Once injected, the product gradually disperses beneath the skin, where it may help improve the appearance of skin texture and elasticity over time. It is commonly used on the face, neck, and décolletage, and is usually administered over a course of two or more sessions, depending on your individual needs.

✨ Reported Benefits of Profhilo

Profhilo is often chosen by clients who are looking to support their skin's overall appearance without adding volume. While outcomes vary between individuals, clients commonly report:

• A more hydrated and balanced skin appearance

• Smoother-looking skin with improved texture

• A refreshed and radiant complexion over time

• Subtle changes in the look and feel of skin laxity

• A natural-looking result with minimal downtime for most people

This injectable treatment may be suitable for areas such as the face, neck, and décolletage, and is often performed as part of a multi-session plan tailored to your goals.

💡 Who Might Consider Profhilo?

Profhilo may be a suitable option for individuals who:

• Experience dry, dull, or dehydrated skin not fully addressed by topical skincare

• Have early visible signs of ageing, such as fine lines or uneven texture

• Prefer a non-volumising treatment that aims to support natural skin quality

• Are noticing mild skin laxity and want a subtle, refreshed appearance

• Seek a treatment with minimal interference with daily activities

A full consultation is required to assess your skin condition and determine if Profhilo is appropriate for your concerns. Treatment plans, expected outcomes, and any risks will be discussed thoroughly.

🔍 Profhilo vs Rejuran: What’s the Difference?

Profhilo and Rejuran are both injectable treatments used to support skin quality, but they contain different active ingredients and are used with different intentions.

🌊 Profhilo

• Contains a high concentration of hyaluronic acid (HA)

• Intended to support skin hydration and a smoother-looking texture

• Commonly used to address dullness, dehydration, or early signs of skin ageing

• Often chosen by clients seeking a refreshed appearance without added volume

• Usually delivered over two sessions, spaced a few weeks apart

🧬 Rejuran

• Contains polynucleotides (PN), which are DNA fragments derived from salmon

• Used with the aim of supporting skin texture, tone, and resilience

• Often considered by individuals with sensitive or uneven-looking skin

• May be suitable for mild concerns such as acne scarring or early visible ageing

• Typically recommended as a course of 3–4 sessions for optimal outcomes

The table below highlights the main differences to help you decide which treatment suits your needs best.

💡 Can Profhilo and Rejuran Be Combined?

Yes — some individuals may choose to include both Profhilo and Rejuran in their treatment plan. These treatments use different active ingredients and are generally considered to have distinct purposes, which may complement each other depending on your skin goals.

• Profhilo is a hyaluronic acid-based injectable that is typically used to support skin hydration and overall quality.

• Rejuran contains polynucleotides (PN) and is often selected by clients looking to improve the appearance of skin texture and tone.

When used in a staggered treatment plan under clinical supervision, this combination may be tailored to suit individuals who wish to address multiple aspects of skin quality — such as dryness, dullness, or uneven texture.

🧑⚕️ Personalised Approach Matters

Your skin’s condition, sensitivity, and treatment goals will all be taken into account by your treating practitioner. Not all treatments are suitable to combine, and a full consultation is required to assess safety, timing, and suitability.

When Might Combination Therapy Be Considered?

Combination therapy may be appropriate in certain situations where multiple treatment approaches are used to support overall skin health and appearance. This approach may be considered for individuals who:

• Are seeking to support skin hydration and texture while also addressing specific concerns such as skin quality or resilience.

• Have a range of skin concerns, such as dryness, changes in skin tone or texture, or the appearance of fine lines.

• Are interested in a broad-based approach to skin ageing, rather than focusing on a single concern.

• Prefer a gradual approach that may lead to subtle and progressive changes over time.

All treatments are tailored to individual needs, and suitability will depend on a full consultation and clinical assessment.

Potential Benefits of Combining Profhilo and Rejuran

When used together, Profhilo and Rejuran may support improvements in multiple aspects of skin health, including:

• Supporting skin texture, tone, and elasticity.

• Helping to address the appearance of fine lines, wrinkles, and scars.

• Contributing to a more refreshed and firmer skin appearance.

• Potentially extending the duration of treatment effects when administered in alternating sessions.

Individual results can vary, and suitability should be determined during a consultation with a qualified healthcare professional.

Which Should You Choose Profhilo or Rejuran?

Choosing between Profhilo or Rejuran depends on your age, skin concerns, and treatment goals. Both are excellent options, but they target different needs.

Factors to Consider

1. Age: Younger patients may benefit from Rejuran’s regenerative properties, while those experiencing early to moderate skin laxity often see better results with Profhilo.
2. Skin Concerns: Consider whether you need hydration, repair, or both.
3. Goals: Are you aiming for smoother texture and scar reduction, or overall firmness and glow?

Rejuran: If your main concerns are acne scars, rough skin texture, or dull and tired-looking skin, then Rejuran is often the better choice. It works at a cellular level to repair damage, stimulate healing, and reduce fine lines. Rejuran is also well-suited for individuals with sensitive or easily damaged skin who want long-term regeneration and stronger skin health.

Profhilo: If your goal is deep hydration, improved elasticity, and a natural anti-aging glow, then Profhilo may be more suitable. By delivering high concentrations of hyaluronic acid, Profhilo helps plump the skin, restore firmness, and enhance overall radiance. It is ideal for those looking to combat sagging, dryness, or early signs of aging with natural, glowing results.

Treatment Experience

Both Profhilo and Rejuran are administered through a series of tiny injections into targeted areas of the skin. The treatment usually takes 20–30 minutes and is performed in a clinic setting by a qualified professional.

Pain/Discomfort Levels

• Profhilo: Generally mild discomfort as it uses fewer injection points (often 5 on each side of the face).
• Rejuran: May feel slightly more uncomfortable because it requires multiple micro-injections across the treatment area. A topical numbing cream is typically applied to reduce pain.

Recovery Time

• Profhilo: Small bumps or redness may appear at injection points but usually settle within 24–48 hours.
• Rejuran: Slight swelling or pinpoint marks may last 2–3 days before fading.

Both profhilo and rejuran treatments involve minimal downtime, and most patients can return to daily activities the same day.

Cost of Profhilo vs Rejuran Treatments

The cost of Profhilo and Rejuran treatments can vary depending on the clinic, city, and the number of sessions required.

Profhilo: Typically most patients needing 2 sessions about 4 weeks apart. Results last around 6–9 months.

Rejuran: Usually requires 3–4 sessions for best results. Outcomes can last 6–12 months depending on skin condition.

Conclusion

In the debate of Profhilo vs Rejuran, the best choice depends on your skin’s needs. Profhilo is ideal for hydration, firmness, and glow, while Rejuran excels in repair, healing, and regeneration. For many patients, combining both delivers the most comprehensive results. Always consult a qualified practitioner to determine the right treatment for your skin goals.

FAQs

Is Rejuran or Profhilo better for anti-aging?

Both can address signs of aging, but in different ways. Profhilo is excellent for improving hydration, firmness, and glow, while Rejuran focuses on cellular repair and reducing fine lines. Many patients combine them for optimal results.

Can you do Profhilo and Rejuran in the same session?

Yes, they can be used together since they serve different purposes. Some clinics recommend alternating or combining them for enhanced results, depending on your skin concerns.

How long do results last?

Profhilo: Around 6–9 months, depending on age and lifestyle. Rejuran: Around 6–12 months, depending on skin condition and number of sessions.

Which has less downtime?

Profhilo generally has less downtime since it uses fewer injection points. Rejuran may leave slightly more swelling or redness, lasting up to 2–3 days.